International UN Peacekeeper in Liberia Tests Positive for Ebola

THE ASSOCIATED PRESS By JONATHAN PAYE-LAYLEH and MIKE CORDER                                                Dec. 5, 2014

MONROVIA- A U.N. peacekeeper who contracted Ebola in Liberia will be flown to the Netherlands for treatment, a Dutch Health Ministry spokeswoman said Friday.

The Nigerian soldier is expected to arrive in the Netherlands this weekend and will go into isolation at the University Medical Center Utrecht, according to Inge Freriksen.

This is the third infection for the mission, which comprises about 7,700 troops and police. The previous two died.

Sixteen people who came into contact with the Nigerian soldier have been quarantined, the mission said.

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http://abcnews.go.com/International/wireStory/peacekeeper-liberia-tests-positive-ebola-27383914

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Number of Ebola deaths could be cut by use of basic measures, say experts

THE GUARDIAN  by in Freetown and
Dec. 5, 2014

Basic medical interventions such as giving Ebola patients rehydration salts and fluids from bigger bags could cut the death toll in west Africa in the absence of a proven cure, experts in tropical diseases write on Friday in the Lancet.

The doctors say it is “therapeutic nihilism” to assume there is no treatment for Ebola just because there are no drugs. It is likely, they say, that many patients die because of dehydration.

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Liberia Bans Election Rallies to Fight Ebola

UPDATE: Liberia court suspends ban on mass gatherings in Monrovia

MONROVIA --Liberia's top court issued a stay on a government order banning public gatherings in the capital ahead of Senate elections next week that was imposed because electioneering risks spreading Ebola, Information Minister Lewis Brown said on Sunday.

Presiding Associate Justice Philip

On Monday, the court will hear a petition by civil society groups, prominent citizens and some political parties who seek a delay to the Senate elections, now set for Dec. 16, until Ebola is eradicated.

On Wednesday, the court will hear a separate petition by independent Senate candidate Robert Sirleaf, the son of President Ellen Johnson Sirleaf.

issued the stay pending two Supreme Court hearings this week, Brown said.

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Cooler box-equipped motorbikes donated to UN will speed up Ebola testing process in West Africa

UNITED NATIONS NEWS CENTRE                                                                             Dec. 4, 2014
Four hundred motorbikes equipped with cooler boxes will help speed up deliveries of blood samples to laboratories from remote areas of Guinea, Liberia and Sierra Leone and reduce the waiting time for Ebola test results, thanks to a donation today from Germany to the United Nations.

Four hundred cooler box-equipped motorbikes for the Ebola Response were officially handed over to the UN Humanitarian Response Depot by German Ambassador to Ghana Ruediger John, and will be used to bring blood samples to labs in the most affected areas of Sierra Leone, Liberia, and Guinea. UNMEER Photo/Martine Perret

At UN Headquarters, meanwhile, UN Secretary-General Ban Ki-moon told reporters that the immediate priorities of the United Nations are to stop the virus and to treat all the people who have Ebola. “We have to ensure that all essential services are provided, and also we have to help them preserve their social and political stability, and keeping a further outbreak from happening.”

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U.S. is weighing more aid to fight Ebola in Sierra Leone

                                             Dec. 14, 2014

The United States is weighing an increase in aid, including a possible military component, to help fight the Ebola outbreak in Sierra Leone, the country in West Africa where the deadly virus is spreading the fastest, officials said Thursday.

“We are looking at what more can be done in Sierra Leone, recognizing that is the forefront when it comes to the virus, and we’re clearly looking at all options,” said a senior administration official who spoke on the condition of anonymity because he was not authorized to discuss policies that are being formulated.

“Nothing is off the table,” he said. “If we determine that only the U.S. military with its unique capabilities can bring this under control, it is something we are willing to consider.”

Among the options is shifting foreign medical teams from­ ­Liberia to Sierra Leone, said ­Andrew Weber, the State Department’s deputy coordinator for Ebola response, in an interview.

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What Ebola Is Teaching Us About Hard Trends

WIRED     Essay by David Burris                                                                                        Dec. 14, 2014

...Deadly and infectious viruses such as Ebola are an inevitable and unavoidable fact of nature. In other words, they are examples of a Hard Trend. And they demand new innovations in order to combat them.

...the deadly force of Ebola is the kind of imminent threat that inspires human minds to new heights. It teaches us that Hard Trends come at us fast and provide the catalyst to overcome inertia and bring about technological innovations.

NIAID/Flickr

Communication is key to mobilizing populations in countries affected by Ebola. In order to treat the sick and prevent the spread of the disease, healthcare workers need to be able to coordinate with people on the frontline and know where to send supplies. At the moment, telecommunications technologies are not keeping pace with the intense demands that Ebola creates.

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Ebola Free-for-All Could Trigger Bad Science and Wasted Efforts

Everybody and his uncle, it seems, has an idea of something that might work to cure people infected with the deadly virus

 SCIENTIFIC AMERICAN    By Helen Branswell                        Dec. 4, 2014

When it comes to treatments for Ebola, there has been a nearly four-decade-long drought. Nothing in the medical arsenal attacks the virus directly....

 

 

 

Dr. John M. Dye, Jr., U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) Viral Immunology branch chief, works in a laboratory at the USAMRIID headquarters in Frederick, Maryland. Dr. Dye is leading a team that is conducting a study with nonhuman primates involving the experimental drug ZMapp, an experimental treatment for Ebola patients. Credit: CDC

 

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Pentagon Scaling Back Military Effort to Contain Ebola

MILITARYNEWS.COM  by Richard Sisk                            Dec. 3, 2014

The U.S. military was scaling back its efforts against Ebola in Liberia amid encouraging signs of progress against the epidemic, Army Gen. David Rodriguez said Wednesday.

 

U.S. personnel construct the Monrovia Medical Unit site in Monrovia, Liberia. The MMU is being constructed in the event any medical workers in the area catch Ebola while assisting in Operation United Assistance. Craig Philbrick/Army

The military initially planned to construct 17 treatment centers of 100 beds each in Liberia, but will now set up 10 centers for virus victims. The first three centers will have 100 beds, but the remaining seven will have 50 beds, Rodriguez, head of U.S. Africa Command, said at a Pentagon briefing.

Rodriguez also said the military was looking at possibly easing the 30-day quarantine period for troops returning from West Africa. However, he stressed that no decisions had been made.

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Ebola Spreading Faster in Sierra Leone

VOICE OF AMERICA                                      Dec. 3, 2014

New data shows the Ebola outbreak intensifying in Sierra Leone, even as it stabilizes or drops off in other West African countries.   (Scroll down for link to WHO roadmap.)

The World Health Organization says Sierra Leone reported 537 new confirmed cases in the week ending November 30, a jump of more than 150 over the week before.  

In its latest update Wednesday, the WHO says "transmission remains persistent and intense across the country with the exception of the south."  The worst affected area was the capital, Freetown, where more than 200 new cases were reported.  

According to the WHO, the number of Ebola cases worldwide is more than 17,000, with all but a few dozen in Sierra Leone, Guinea and Liberia.  The overall death toll is up to 6,070.

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http://www.voanews.com/content/ebola-spreading-faster-in-sierra-leone/2544743.html?utm_source=December+4+2014+EN&utm_campaign=12%2F4%2F2014&utm_medium=email

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Evaluating Ebola Therapies — The Case for RCTs

THE NEW ENGLAND JOURNAL OF MEDICINE                                                                                 Dec. 3, 2014
By Edward Cox, M.D., M.P.H., Luciana Borio, M.D., and Robert Temple, M.D.

...Studying investigational therapies for EVD presents scientific, practical, and ethical challenges. Not surprisingly, there has been substantial debate about the best and most appropriate study approaches.2,3 It is generally agreed that a trial with a concurrent control group, in which patients are randomly assigned to receive the test drug plus the best available supportive care (BASC) or to BASC alone, would be the most efficient and reliable way to evaluate the safety and effectiveness of candidate products.

 Some people in the health care community, however, have argued against such trials, urging instead use of a historical control — that is, making investigational drugs as widely available as their supply allows and then comparing mortality rates among treated patients with rates that would have been expected absent the drugs, on the basis of past experience with EVD.

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Ebola deals a blow to Morocco's Africa plans

INSTITUTE FOR SECURITY STUDIES                                                                                Dec. 2, 2014

Morocco’s refusal to host the Africa Cup of Nations (Afcon) from 17 January to 8 February next year, due to fears of Ebola,has sparked a furore among soccer lovers across the continent.

The North African kingdom has since become the target of some of the most aggressive xenophobia from fellow Africans, notably on social media. ‘Morocco is scared of outsiders,’ ‘Morocco is not an African country,’ are some of the insults that have been directed at the country in the wake of its decision.

... The competition has now been moved to Equatorial Guinea, co-host of the 2012 Afcon with Gabon. This decision has huge financial and political implications. Morocco has also been barred from participating in the 2015 Afcon, and risks more sanctions for its national team and Moroccan clubs.

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Five million children out of school in West Africa due to Ebola

REUTERS-by  Misha Hussain                                   Dec. 3, 2014

DAKAR, Senegal   - Some five million children are out of school in Guinea, Liberia and Sierra Leone because of the deadly Ebola outbreak, according to a report by the Global Business Coalition for Education.

A man walks by a mural with health instructions on treating the Ebola virus, in Monrovia, November 18, 2014. Credit: Reuters/James Giahyue

Schools and other public buildings have been closed because they are believed to increase the spread of the virus. Many are now used as holding centers for Ebola patients.

The report, co-written with A World at School, said being out of school can have a crippling impact on vulnerable children, especially girls, who are more likely to face high-risk situations as a result, including early marriage and pregnancy.

If schools are not reopened, the most vulnerable children will become trapped in a cycle of poverty with devastating consequences for their health and economic development, the report said.

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Finding the Ebola virus’ vulnerable points

Three copies of the Ebola glycoprotein (blue) with antibodies (yellow) latched on to them. Picture by Stanfordby Shalini Saxena - Nov 30 2014 - http://arstechnica.com

We know what antibodies stop it in its tracks—we now know where they attach.

The latest Ebola outbreak has dwarfed any that have occurred since the discovery of the virus in 1976; previous outbreaks have had lethality rates of up to 90 percent. Yet no vaccines or therapies are currently approved for human use, which limits our ability to treat patients and contain the outbreak. Mixtures of monoclonal antibodies (see sidebar) are a potential treatment option that has been used experimentally.

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U.N. Mission Warns That Ebola Still Poses ‘Huge’ Global Threat

A mother and child stand atop their mattresses in a classroom now used as Ebola isolation ward on Aug. 15, 2014, in Monrovia, Liberiaby Elizabeth Barber - Dec. 1, 2014 - time.com

The U.N. mission is urging that the longer the disease is allowed to storm West Africa, the more likely it is that the virus will reappear elsewhere in the world.

The head of the U.N. Ebola mission in West Africa has said there is a “huge risk” of the Ebola outbreak expanding beyond the hard-hit region.

https://time.com/3611314/u-n-ebola-global-threat-anthony-banbury-bbc/

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WHO Says Liberia, Guinea Meeting Ebola Targets

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