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How Technology Can Help Reboot Ebola-Free Sierra Leone

submitted by George Hurlburt  

             

The new Sensi Technology Innovation Hub hopes to help the country rebuild after its Ebola crisis

cnn.com - by Peter Guest - November 7, 2015

(CNN) - Morris Marah was working in the Sierra Leonean High Commission in London when the devastating Ebola outbreak struck his country last year.

Desperate to help, he went home; first to volunteer in a community health center, then by applying his technology skills to build an SMS-based platform that disseminated weekly information and advice on how to avoid contracting the disease to more than 500,000 people.

"I felt, sitting in London there wasn't much I could do from that far away. I wanted desperately to come out here and see how I could be useful," he says over the phone from the capital, Freetown.

Working on that platform, called Sensi, and on other public health initiatives demonstrated how successfully technology could be leveraged for social good, and inspired him to look for ways to bring the country's small, but talented, tech community together to help restart the country's stalled economy.

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Each 1-Day Delay in Hospitalization Ups Risk of Ebola Death

US NEWS AND WORLD REPORT HEALTHDAY NEWS by Robert Preidt,  Nov. 6, 2015

Ebola patients are more likely to survive if they are hospitalized soon after being infected, a new study finds.

Researchers analyzed data from nearly 1,000 cases of Ebola virus that occurred in the Democratic Republic of Congo over 38 years. They found that each day of delay in hospital admission was associated with an 11 percent higher risk of death during epidemics.

Delays in hospitalization were caused by factors such as geography, infrastructure and cultural influences, the researchers said.

The Democratic Republic of Congo has had more Ebola outbreaks than any other country since the deadly virus was discovered in 1976, they noted.

The researchers also found that rapidly progressing Ebola outbreaks are swiftly brought under control, while national and international responses to slower-progressing outbreaks tend to be less intense. As a result, those outbreaks last longer, the study authors said.

The study was published Nov. 3 in the journal eLife.

Read complete story.

http://health.usnews.com/health-news/articles/2015/11/06/each-1-day-delay-in-hospitalization-ups-risk-of-ebola-death

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To Prevent Malaria in Humans, Scientists Try Protecting Pigs

 New York TImes, November 2, 2015

http://www.nytimes.com/2015/11/03/health/to-prevent-malaria-in-humans-scientists-try-protecting-pigs.html?_r=1&WT.mc_id=SmartBriefs-Newsletter&WT.mc_ev=click

 

 

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G7 Health Ministers Propose Incentives For New Antibiotics, Commit Help On Ebola

INTELLECTUAL PROPERTY WATCH by Catherine Saez, Oct, 12, 2015

(Scroll down for Ministers' Statement.)

The health ministers of the Group of Seven (G7) most developed countries have issued a declaration on antimicrobial resistance and Ebola. The governments said they would explore innovative economic incentives to promote research and development of new antibiotics, such as a global antibiotic research fund and a market entry reward mechanism.

The G7 (Canada, France, Germany, Italy, Japan, United Kingdom, and United States) met from 8-9 October in Berlin and agreed to the Berlin Declaration [pdf] on Antimicrobial Resistance – Global Union for Antibiotics Research and Development (GUARD), aimed at supporting developing countries to develop national antimicrobial resistance action plans.

The G7 health ministers also issued a commitment on lessons learned from Ebola, and supported the 2005 World Health Organization International Health Regulations (IHR), insisting on the need to comply with them.

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To Prevent The Next Plague, Listen To Boie Jalloh

When Dr. Boie Jalloh got the call to join the fight against Ebola in Sierra Leone, his friends told him he'd be crazy to sign on. It's a good thing he didn't listen. Aurelie Marrier Dunienville for NPR

Image: When Dr. Boie Jalloh got the call to join the fight against Ebola in Sierra Leone, his friends told him he'd be crazy to sign on. It's a good thing he didn't listen. Aurelie Marrier Dunienville for NPR

npr.org - October 8th 2015 - Amy Maxmen

This is a landmark week in West Africa. For the first time since the Ebola outbreak, there were no new cases reported in Guinea, Liberia and Sierra Leone.

There are many unsung heroes who deserve credit for this milestone. 

(VIEW COMPLETE ARTICLE)

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How Research Data Sharing Can Save Lives

CLICK HERE - WHO - Developing Global Norms for Sharing Data and Results during Public Health Emergencies

blogs.bmj.com - by Trish Groves / The BMJ - September 8, 2015

The whole debate on sharing clinical study data has focused on transparency, reproducibility, and completing the evidence base for treatments. Yet public health emergencies such as the Ebola and MERS outbreaks provide a vitally important reason for sharing study data, usually before publication or even before submission to a journal, and ideally in a public repository.

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CLICK HERE - Wikipedia - Ingelfinger rule

 

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Ebola Assay Card | Elisa-Based Diagnostic - Google Science Fair

submitted by Gavin Macgregor-Skinner

Temperature-Independent, Portable, and Rapid Field Detection of Ebola via a Silk-Derived Lateral-Flow System

googlesciencefair.com - 2015

I developed a “stable and stored at room temperature” Ebola Assay Card, applicable as an ELISA-based diagnostic for diseases such as HIV, Lyme and certain cancers, that will allow for water-activated, timed-release detection of Ebola antigens, with detection limits that are analogous to current sandwich ELISA techniques. Reagents become chemically “stabilized” when mixed into silk, which enables them to remain “chemically active” without refrigeration. This Ebola Assay Card will allow for shipment and storage without refrigeration, and provide detection of the Ebola viral antigens based on color change in as little as 30 minutes.

(CLICK HERE FOR ADDITIONAL INFORMATION)

 

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Fighting Ebola With a Palm-Sized DNA Sequencer

submitted by George Hurlburt

      

Raymond Koundouno using a MinION - Sophie Duraffour

The MinION, a pocket-sized, USB-powered sequencing machine, lets scientists track the spread of deadly diseases in real-time.

theatlantic.com - by Ed Yong - September 16, 2015

. . . Unlike rival sequencers, which are as big as microwaves or fridges, the MinION is the size of a chocolate bar. . . . These devices quite literally bring the power of modern genomics to the palm of your hand. And at a cost of just $1,000, they herald a new era where sequencing moves away from well-equipped institutions and into places where it is most needed, from hospitals to epidemic-afflicted hot zones.

(READ COMPLETE ARTICLE)

(CLICK HERE - MinION - Oxford Nanopore Technologies)

(CLICK HERE - YouTube - MinION - Oxford Nanopore Technologies)

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Social Vulnerability and Ebola Virus Disease in Rural Liberia

      

Clusters of social vulnerability in rural Liberia, by district. Social vulnerability of each cluster of districts can be loosely ranked from most to least vulnerable as: Cluster 1, food quality, displaced persons, disabled, dependent populations; Cluster 3, food quantity, food quality, lack of access to land/free medical care; Cluster 4, food quantity, disabled dependent populations and Cluster 5, water quality/proximity to medical care; and finally, Cluster 2, no strong vulnerability scores.

CLICK HERE - Social Vulnerability and Ebola Virus Disease in Rural Liberia

CLICK HERE - Social Vulnerability and Ebola Virus Disease in Rural Liberia (14 page .PDF file)

srs.fs.usda.gov - by Zoe Hoyle - September 15, 2015

A newly published research study by U.S. Forest Service researchers demonstrates that the social vulnerability indices used in climate change and natural hazards research can also be used in other contexts such as disease outbreaks.

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Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax

                                                     

CLICK HERE - RESEARCH - Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting

prweb.com - by Cynthia Lujan - September 1, 2015

A new host-based therapy for Ebola, anthrax and other deadly infectious diseases has been discovered by researchers at the Keck Graduate Institute and its collaborators. The discovery has the potential to speed to market treatments for previously untreatable diseases.

The findings were published online on August 27 by Scientific Reports, an open access research journal from the publishers of Nature.

The lead authors of the story were Leoor Zilberminitz and William Leonardi, doctoral students in KGI laboratory of assistant professor Mikhail Martchenko. The researchers screened a library of 1,581 drugs previously approved by the FDA for in vitro protection of mammalian cells against Bacillus anthracis lethal toxin and diphtheria toxin, which normally kill 50-70% of unprotected cells. They then investigated the 1% most promising compounds that both provided the best protection against the two toxins and were not toxic to uninfected cells.

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