Sierra Leone

REUTERS by Stephanie Nebehay                                                                        Jan. 22, 2015

GENEVA (Reuters) - The Ebola epidemic in West Africa appears to be ebbing, with fewer than 150 cases reported in the past week, but efforts must be pursued to stamp out the deadly disease, the World Health Organization (WHO) said on Thursday.

Sierra Leone remains hardest-hit, accounting for 117 of the 145 new confirmed cases, against 184 there the previous week and 248 the week before that, the WHO said in its latest update.

"Case incidence continues to fall in Guinea, Liberia, and Sierra Leone," the United Nations agency said, adding that disease surveillance was being stepped up in border districts of Guinea-Bissau, Ivory Coast, Mali and Senegal....

The WHO's Emergency Committee on Ebola said on Wednesday that passengers should still be screened on leaving Guinea, Liberia and Sierra Leone for temperature or other signs of infection.

The independent experts said in a statement that "more than 40 countries have implemented additional measures, such as quarantine of returning travellers and refusal of entry. Such measures are impeding the recruitment and return of international responders.

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BALTIMORE SUN     by Scott Dance                                                   Jan. 20, 2015

In the year since Ebola began spreading across West Africa, the virus has mutated in more than 600 ways that change it slightly from versions studied in labs and used to develop treatments, according to researchers at Fort Detrick. And 10 of the mutations could make some drugs used to treat the virus ineffective, they wrote in research published Tuesday.

The "genomic drift," as the scientists called it, could make agents similar to the experimental drug ZMapp unable to bind to the virus anymore.

While the changes affect only a tiny fraction of Ebola's genome, they offer new lessons about the virus that might not have been learned because of the wide scope of the outbreak, larger than all others combined
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http://www.baltimoresun.com/health/bs-hs-ebola-mutation-20150120-story.html

BBC  by Joe Miller                                                                                                    Jan. 21, 2015
DAVOS Switzerland -- The Western world is "vulnerable" to epidemics such as Ebola, and must invest more in researching vaccines, a leading scientist has warned.

Prof Peter Piot told the BBC that developed nations would be in "deep trouble" if they failed to adequately prepare for another outbreak.

Speaking at the World Economic Forum, in Davos, he urged global leaders to take a "long-term view". Public health policies must "transcend politics and borders", he said.

The threat of Ebola, and other infectious diseases such as influenza and Sars, are set to be discussed in Switzerland this week, as politicians and business leaders from around the globe gather for the annual WEF.

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http://www.bbc.com/news/business-30907630

Ebola treatment centres have often not been completed until the virus has passed its peak.
Photograph: Francisco Leong/AFP/Getty Images

UN’s lead Ebola co-ordinator en route to Davos says last third of the $1.5bn pledged to tackle disease needs to be paid in order to end the outbreak

theguardian.com - by Sarah Boseley - January 20, 2015

Half a billion dollars of aid pledged to end the Ebola outbreak in west Africa still hasn’t been paid, according to the UN’s response co-ordinator.

Dr David Nabarro, in London and on his way to Davos to discuss progress against Ebola and future plans, said about two-thirds of the promised $1.5bn had been paid so far. “This last third is the most precious money but probably the most difficult money,” he told the Guardian. “My focus over the next few days here and in Davos is trying to ensure we have enough money to enable the task to be completed.