OMAHA WORLD-HERALD by  Bob Glissman                                                             March 11, 2015

  The West African countries hit hardest by the Ebola virus and the countries and groups that have helped battle the disease must remain vigilant if the number of new Ebola cases is to get to zero, health experts said Wednesday.

Dr. Ali Khan, dean of the University of Nebraska Medical Center’s College of Public Health, spent a month in Sierra Leone as a consultant on Ebola for the World Health Organization. 

Dr. Ali Khan, who returned to Omaha late last week after a month in Sierra Leone, said progress is evident, but he cautioned officials there against becoming complacent. “Because with a disease like Ebola,” he said, “all you need is one case to restart an outbreak or a cluster of cases.”

REUTERS  by Misha Hussain                                                    March 12, 2015sC

(Scroll down for links to press release and full report.)

DAKAR -- West Africa may lose up to $15 billion over the next three years due to the impact of the Ebola outbreak on trade, investment and tourism, according to a report by the United Nations.

The world's deadliest Ebola epidemic has killed almost 10,000 people in the three most affected countries of Guinea, Liberia and Sierra Leone, deepening poverty in one of the least developed parts of the world.

"The consequences of Ebola are vast," said Abdoulaye Mar Dieye, Africa director of the United Nations Development Programme (UNDP).

"Stigma and risk aversion have caused considerable amounts of damage, shutting down borders and indirectly affecting the economies of a large number of countries in the sub-region."

Read complete story

http://news.yahoo.com/ebola-could-cost-west-africa-15-billion-over-150805196.html;_ylt=AwrBJSCTtwFVoAIAda3QtDMD

NEW YORK TIMES  by Rick Gladstone                                                                   March 12, 2015 

The president of Liberia acknowledged on Wednesday that she had erred in ordering a tough security crackdown at the height of the Ebola crisis last year, describing the deadly virus as an “unknown enemy” that had frightened her.

Liberian President Ellen Johnson Sirleaf during a video address last Deceber to the Senate Foreign Relations Committee

SCIENCE By Kai Kupferschmidt                                                                       March 11, 2015

Researchers in Sierra Leone today started a new phase II trial of an experimental drug in Ebola patients. The first participant received an injection of the therapeutic, called TKM-Ebola, this morning at an Ebola treatment unit in Kerry Town. The trial may expand to other sites; the study team hopes to have an answer fast so that it can either move on to another drug or start a phase III study of TKM-Ebola.

Produced by Tekmira Pharmaceuticals in Burnaby, Canada, TKM-Ebola is made of synthetic, small interfering RNAs packaged into lipid nanoparticles. The RNAs target three of Ebola’s seven genes, blocking the virus’s replication. TKM-Ebola has been shown to work well in monkeys; the efficacy trial in humans is only starting now because there was not enough of the drug available earlier. Also, the RNAs have been adapted to the strain circulating at the moment.

The study does not have a placebo arm; all patients at the trial site are eligible for the drug, and researchers hope to determine whether it works by comparing them with patients treated elsewhere.

AFP                                                                                                                       March 11, 2015

Geneva  - No new case of the deadly Ebola virus has been registered in Liberia since February 19, the World Health Organization said Wednesday, also hailing positive signs in Sierra Leone and Guinea.

                      A man walks past an Ebola campaign banner with the new slogan "Ebola Must GO" in Monrovia

Liberia, long the hardest-hit country in the Ebola epidemic that has killed nearly 10,000 people in west Africa, "has now gone well over two weeks without a new reported case," said Bruce Aylward, who heads WHO's Ebola response....

The outlook was less positive in the other countries affected by the outbreak, Guinea and Sierra Leone, although Aylward highlighted positive signs there too.
Read complete story.
http://news.yahoo.com/no-ebola-cases-liberia-more-two-weeks-175855158.html;_ylt=AwrBJR9j5gBVAQYArDLQtDMD

REUTERS     by Tom Miles                                                                                        March 11, 2015

GENEVA -Waning interest in Ebola could jeopardize efforts to stamp out the world's worst recorded outbreak of the disease, the World Health Organization said on Wednesday.

Case numbers have fallen to a low level and it should be possible to stop transmission by mid-year, but the disease is "not waning" and it is much too early to assume the outbreak will end, said WHO Assistant Director General Bruce Aylward.

"We talk often about how steep the drop in cases has been. The only thing that has dropped more quickly and more steeply is the new contributions in financing," he told reporters in Geneva. 

...the failure to make further inroads is "alarming", Aylward said.

"Getting from here to zero is going to require another reinvestment (in the drive to tackle the outbreak)."

CLICK HERE - AUDIO - MEETING
The State of African Resilience
March 11, 2015 - 2:00pm-4:00pm
Center for Strategic & International Studies (CSIS)

Understanding Dimensions of Vulnerability and Adaptation

CLICK HERE - REPORT - The State of African Resilience
(72 page .PDF Report)

csis.org - by Jennifer G. Cooke - March 11, 2015

savethechildren.org

CLICK HERE - REPORT - A WAKE-UP CALL - Lessons from Ebola for the world’s health systems (50 page .PDF report)

nytimes.com - by Donald G. McNeil Jr. - March 9, 2015

The world has spent more than $4 billion fighting Ebola, but according to a new report from Save the Children, it would have cost only $1.6 billion to bring health care systems up to minimum standards in Sierra Leone, Liberia and Guinea, which might have prevented the outbreak or ended it faster.

Even before Ebola struck West Africa, more than 25 countries had health care systems worse than those in impoverished Liberia and Sierra Leone, the report also found.

Researchers are scrambling to start trials before the outbreak fades, but establishing faith in vaccines will take time

AL JAZEERA AMERICA  by Amy Maxmen                       March 11, 2015

FREETOWN, Sierra Leone — Since Ebola hit this coastal city last summer, nurses at Connaught Hospital have put their lives on the line by working with patients at risk of the deadly disease. Now researchers aim to recruit them as well as ambulance drivers and other hospital staff as subjects in one of the largest Ebola vaccine trials to date.

But just a few weeks before the trial begins enrollment, many health care workers are voicing discomfort about the shot. “It would be really good to have a vaccine, but we’re scared because it’s new,” said Kadiatu Nubieu, a nurse at Connaught.

policy-practice.oxfam.org.uk - Authors: Cairns, Edmund
February 27, 2015 - ISBN: 978-1-78077-825-9

In Sierra Leone and Liberia, thousands of local people have taken part in campaigns to spread the message about how Ebola can be controlled, and millions have taken vital practical steps to prevent infection. When the last case of Ebola is eliminated, it will not only be because of medical treatment and action by governments and the international community, but because communities have been at the heart of the response. Before Ebola struck West Africa, Liberia and Sierra Leone were among the poorest countries in the world – now they are even poorer. The challenge of recovery is enormous and communities must once again be at the heart of it. Oxfam has listened to women and men in Liberia and Sierra Leone to hear their priorities for the immediate response, the recovery and beyond. This paper presents those priorities, from rebuilding shattered livelihoods and building a resilient health service, to making schools safe and free for all.

ebolaresponse.un.org

Coalition Meeting Notes - Minutes from the weekly meetings held by the Global Ebola Response Coalition:

Global Ebola Response Coalition Meeting 21 | 6^th March 2015:

Issues Discussed and Next Steps

The twenty first meeting of the Global Ebola Response Coalition Core Group took place on 6 March. The main points covered in the meeting follow.

2.            Participants discussed the status of the outbreak.  The cumulative number of people who have been diagnosed with Ebola in the current outbreak is now 23,983. The number of people newly diagnosed with Ebola in the 7 days to 1 March, is 132; the figure was 99 in the preceding 7 days. This week’s total reflects increases in Guinea (35 to 51) and Sierra Leone (63 to 81) but a fall in Liberia (1 to 0). The volatility in numbers of people newly diagnosed with Ebola each week continues: the figure ranges between 90 and 160 new cases per week.  The majority of new cases are reported from the geographical region around the coastal border areas between Guinea and Sierra Leone.

WHO PRESS RELEASE                                                March 10, 2015

The WHO Director-General has commissioned a panel of outside independent experts to undertake an assessment on all aspects of WHO’s response in the Ebola outbreak. This is in response to a resolution passed during the Ebola Special Session of the Executive Board in January 2015.

Dame Barbara Stocking will chair the panel. She was formerly Chief Executive of Oxfam GB (2001-13) and during this time led major humanitarian responses. Currently she is President of Murray Edwards College, University of Cambridge, UK.

The other panel members are: Professor Jean-Jacques Muyembe-Tamfun, Director-General of the National Institute for Biomedical Research, Democratic Republic of the Congo; Dr Faisal Shuaib, Head of the National Ebola Emergency Operations Center, Nigeria; Dr Carmencita Alberto-Banatin, independent consultant and advisor on health emergencies and disasters, Philippines; Professor Julio Frenk, Dean of the Faculty, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA; and Professor Ilona Kickbusch, Director of the Global Health Programme at the Graduate Institute of International and Development Studies, Geneva, Switzerland.

The panel will present a first progress report on its work to the 68th World Health Assembly in May 2015.

THE ECONOMIST                                                                                                   March 9, 2015

As in all Ebola episodes, preventing infection in West Africa during what has been the worst outbreak in history has placed a lot of effort on looking after those dealing with the victims. New high-tech equipment is now available for use by health care workers, but in some countries it may be inappropriate....

Health care workers inside a USAID-funded Ebola clinic in Liberia wearing protective gear. Some of the best protective gear or technology is not available to African countries because of high costs or other conditions.  Photos by Abbas Dulleh • Associated Press,

MAD in AMERICA                                                                                        March 9, 2015

What's the key to rebuilding Liberian communities and igniting the country's economic recovery in the wake of the devastation of the Ebola epidemic and civil war? Expanding mental health services, reported articles in Nature, Devex, StarAfrica and other outlets.

A new three-year, $3 million effort to expand mental health services in Liberia is being funded by the government of Japan through a World Bank-administered trust fund, reported Devex. "Developers of the project hope that an increased focus on mental health will help spur economic recovery and growth in the devastated region by helping build social capital and community trust, while fostering positive coping behaviors," stated Devex. "A new squad of child mental health clinicians will be deployed to approximately 60 schools, while community-based interventions beyond Ebola-affected communities will be strengthened...."

MEDICALXPRESS                                                                                                 March 9, 2015
Researchers from Emory and the Centers for Disease Control and Prevention have now obtained a first look at the immune responses in four Ebola virus disease survivors who received care at Emory University Hospital in 2014, by closely examining their T cells and B cells during the acute phase of the disease. The findings reveal surprisingly high levels of immune activation, and have implications for the current effort to develop vaccines against Ebola.

The Ebola virus, isolated in November 2014 from patient blood samples obtained in Mali. The virus was isolated on Vero cells in a BSL-4 suite at Rocky Mountain Laboratories. Credit: NIAID