AFP                                                                                                   March 25, 2015

Paris - The latest in a string of candidate vaccines against the deadly Ebola virus was proven safe in an early trial in healthy adults in China, its developers said Wednesday.

Dubbed Ad5-EBOV, the vaccine is the first based on the strain of the Ebola virus behind the west African outbreak, according to a paper published in The Lancet medical journal.

Read complete story.
http://news.yahoo.com/ebola-trial-vaccine-safe-researchers-140735607.html;_ylt=AwrBJR6SwhJVFgkANl3QtDMD

Read Lancet article.

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2815%2960553-0/abstract

A new study shows the durability of a novel 'disseminating' cytomegalovirus (CMV)-based Ebola virus (Zaire ebolavirus; EBOV) vaccine strategy that may eventually have the potential to reduce ebolavirus infection in wild African ape species.

These are western lowland gorillas, one of the great ape species threatened by Ebola. Credit: Copyright 2012 Chris Whittier

A cytomegalovirus (CMV)-based vaccine provides long-lasting protective immunity against Ebola virus, and has potential for development as a disseminating vaccine strategy to prevent ebolavirus infection of wild African ape populations.

The multi-institutional study is led by Dr Michael Jarvis at Plymouth University, and is published today, 25th March 2015, in Vaccine.

Health workers in protective clothing speak with new arrivals in the outpatient waiting room of Redemption Hospital, formerly an Ebola holding centre, in Liberia.  John Moore/Getty Images

CLICK HERE - SCIENCE - REPORT - Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

businessinsider.com.au - by Chris Pash - February 27, 2015

A chemical found in the Chinese herb known as Han Fang ji switches off the channels which the Ebola virus uses to enter and infect cells, according to research by US and German scientists.

The scientists found that using a small dose of the chemical tetrandrine, but not the herb itself, stopped the virus from replicating and protected mice from the disease without obvious side effects.

The discovery of the promising drug therapy against Ebola is announced in the journal Science.

(READ COMPLETE ARTICLE)

africansuntimes.com - by Mardia Stone, M.D. - March 23, 2015

On March 20^th, a newly confirmed Ebola case was reported [in Liberia] . . . This time, sexual contact is presumed to be the hidden culprit in this new Ebola virus transmission, according to a statement from the Ministry of Information and case reports from the National Ebola Response Team.

The story goes like this. . . .

(READ COMPLETE ARTICLE - PLEASE ALLOW ADDITIONAL TIME FOR POSSIBLE SLOW-LOADING SITE)

(ALSO SEE RELATED INFORMATION HERE)

As the Ebola epidemic draws gradually to its close, how should the world arm itself against the risks of insurgent infections?

 THE ECONOMIST                                                                                        March 21,  2015

The BBC   by Hans Rosling                                                                    March 23, 2015
Interview with Swedish statistician and global health professor Hans Rosling who spent three months working as an epidemiologist in the Liberian Health Ministry helping to tackle the Ebola crisis.

                  Hans Rosling flanked by Maj Morris Hunh (China), to his right, and Gen Gary Volesky(U.S.) to his left

Excerpt from BBC interview:

The curve turned around because enough Ebola treatment units were built. Medecins Sans Frontieres ran the biggest. When that was not enough, Liberian doctors and nurses added the next treatment unit. But the race against time in September to provide treatment and isolation for all patients, when the epidemic curve climbed to 30, 40 and 50 patients per day, was won by the WHO.

 By the end of September, Dr Atai from Uganda opened the so-called Island Clinic which meant beds could be offered to all Ebola patients.The curve was curbed for four reasons:

INFECTION CONTROL TODAY                                      March 24, 2015
The World Health Organization (WHO) is publishing a series, "Ebola Diaries," with first-person accounts of WHO staff and others deployed to the field for Ebola response since the first cases were reported in West Africa on March 23, 2014.
 
Dr. Stéphane Hugonnet, team lead for gobal capacities, alert and responses for the World Health Organization (WHO), was one of the first WHO experts sent to Guinea to investigate cases of Ebola reported in late March 2014. A medical doctor who has spent the past 20 years working for WHO, MSF and others, managing outbreaks ranging from cholera, measles and yellow fever, to Lassa, Ebola and meningitis, Hugonnet found a very different sort of outbreak when he arrived in Guinea.

"We were following this rumor of a small cluster of unexplained deaths in Guinea," he says. "Some thought it could be Lassa    phane fever, but the transmission pattern was very compatible with Ebola. When the lab results came back, we learned that there was Ebola Zaire in West Africa.            

TECH REPUBLIC  by Mary Shaklett                                                                         March 24, 2015

Big data practitioners are learning that the laboratory know-how of computer scientists and statisticians must be matched with a holistic, 360-degree vision of the problem to be solved. TheEbola crisis is a prime example....

If big data is going to help solve health issues like Ebola, it must be incorporated into analytics that consider all of the factors shaping the epidemic. These are three of the ingredients that should be factored into Ebola analytics.

1: There are political barriers that stand in the way of obtaining data from cell phone providers that could assist researchers in determining where the disease will strike next.

2: Even if disease researchers could obtain this data, there is a need to "correct" the data for what it doesn't reveal. For example, if less than 50% of a country's population has access to mobile phones and individuals are constantly moving from village to village, how will researchers be able to verify the quality of the data they're getting unless there are people "on the ground" who can verify or provide corrective factors to the data?

sciencedirect.com - June 2014
Justin Stoler, Rawan al Dashti, Francis Anto, Julius N. Fobil, Gordon A. Awandare
doi:10.1016/j.actatropica.2014.02.017

CLICK HERE - Deconstructing “Malaria”: West Africa as the Next Front for Dengue Fever Surveillance and Control

Highlights

• Febrile illnesses are vastly overdiagnosed as malaria in many African settings.

• West Africa is emerging as a new front for dengue fever surveillance and control.

• Efficient health care utilization depends upon proper diagnosis of febrile illness.

REUTERS by Emma Farge                                             March 23, 2015

DAKAR, March 23 -- Lapses that fueled the Ebola outbreak after it was first discovered a year ago are dogging the final stages of the fight against the virus as fatigue and complacency set in, delaying the end of the deadly epidemic.

A man is sprayed with disinfectant after he celebrated the memory of a loved one who died due to the Ebola virus at a newly build grave yard for Ebola virus victims in Monrovia, Liberia, Wednesday, March 11, 2015. Liberians held a church service Wednesday for families who lost members to Ebola to mark the country’s 99th celebration National Decoration Day, a holiday normally set aside for people to clean up and re-decorate the graves of their lost relatives. (AP Photo/Abbas Dulleh) | ASSOCIATED PRESS

Three doctors were discovered to be infected with Ebola at a hospital in Guinea's capital Conakry last week in what health reports and government officials blamed on a failure to implement basic measures for infection control.

NATIONAL PUBLIC RADIO by Nurith Aizenman                March 23, 2015

Recruiting and training new health workers is key, because experts warn that unless the health systems in West Africa are brought up to scratch, an epidemic on the scale of this one will happen again.

Unfortunately, building national health systems doesn't tend to attract a lot of love from international donors, says Erin Hohlfelder, who's been pushing for this kind of funding on behalf of the ONE Campaign, a global health advocacy group.

"It's certainly not as 'sexy' — quote unquote — as things like treatment for HIV or bed nets for malaria, which are very tangible and easy to understand."

She says at least for now, the international community does seem to get the importance of building up West Africa's health systems. The governments of the affected countries are preparing national plans to present at a meeting of the World Bank next month

BBC   by  Smitha Mundasad                                                                                        March 23, 2015

The Ebola outbreak in West Africa will be over by August, the head of the UN Ebola mission has told the BBC.

 Ismail Ould Cheikh Ahmed admitted the UN had made mistakes in handling the crisis early on, sometimes acting "arrogantly".

A year after the outbreak was officially declared, the virus has killed more than 10,000 people...

The head of the UN Ebola response mission told the BBC, when the virus first struck, "there was probably a lack of knowledge and there was a certain degree of arrogance, but I think we are learning lessons.

"We have been running away from giving any specific date, but I am pretty sure myself that it will be gone by the summer."

Read complete story.
http://www.bbc.com/news/health-32009508

TIME MAGAZINE  by Helen Regan                                March 23, 2015
(Scroll down for link to full MSF report.)

Paris-based Doctors Without Borders (MSF) has slammedthe international community’s slow response to the Ebola outbreak in West Africa, saying it cost thousands of lives that could otherwise have been saved.

A Doctors Without Borders (MSF), health worker in protective clothing carries a child suspected of having Ebola in the MSF treatment center on October 5, 2014 in Paynesville, Liberia.

The leading international medical charity released a report Monday coinciding with the one-year anniversary of the outbreak’s start. It said warnings that the disease’s spread was out of control were dismissed as alarmist and that early calls for help were ignored by local governments and the World Health Organization (WHO), reports Reuters.

“For the Ebola outbreak to spiral this far out of control required many institutions to fail. And they did, with tragic and avoidable consequences,” said MSF’s general director Christopher Stokes in the report.

IN DEPTH OVERVIEW OF THE EBOLA CRISIS AND LESSONS FOR THE FUTURE
NEW YORK TIMES  by Sheri Fink, MD,   and Pam Belluck                                     March 23, 2015

One year has passed since the declaration of what became the largest Ebola outbreak in history, with more than 10,000 deaths..

Assessing the lessons of an Ebola outbreak that became the largest in history, with 10,000 dead. Credit Daniel Berehulak for The New York Times

ASSOCIATED PRESS  by Jpnathan Paye-Layleh             March 22, 2015

MONROVIA, Liberia — Liberians are overcoming their fears of Ebola to volunteer for a vaccine trial...

One year after the World Health Organization declared the Ebola outbreak, vaccine trials are under way in Liberia and Guinea. Sierra Leone will start a trial later this month.

In Liberia, scientists have fanned out across the country to explain the studies and reduce the fear and confusion that have stymied efforts to contain Ebola.

Dr. Stephen Kennedy, the Liberian lead investigator for the study, was among the first people to volunteer for the vaccine trial, getting his injection in front of the media. Similarly, in Guinea, authorities started the study by injecting a series of prominent officials, including the head of the country's Ebola response.

The outreach worked in Liberia, where more than 700 people have volunteered, well beyond the 600 required, according to Kennedy.

Read complete story.
http://news.yahoo.com/liberians-overcome-fear-volunteer-ebola-vaccine-trial-120848405.html