Overview of what still needs to be learned about the Ebola virus

Research studies have suggested at least three potential paths through which the Ebola virus can invade tissues. Credit Photograph by the C.D.C. via Getty Images

THE NEW YORKER                                      Nov. 1, 2014

By Jerome Groopman

...there are still serious gaps in what we know about the biology of Ebola, and that ignorance inhibits us from preventing future outbreaks and reducing death rates that still exceed seventy per cent. We don’t know enough about the biology of Ebola to bring the outbreak under full control, or to neutralize the virus once the outbreak is contained. Between on-the-ground efforts and advances in science, we need a balanced approach.

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NEW YORK TIMES                               Nov. 1, 2014

By Denise Grady

...The stark difference in the care available in West Africa and the United States is reflected in the outcomes...., In West Africa, 70 percent of people with Ebola are dying, while seven of the first eight Ebola patients treated in the United States have walked out of the hospital in good health. Only one died: Thomas Eric Duncan, a Liberian, whose treatment was delayed when a Dallas hospital initially misdiagnosed his illness.

Dr. Rick Sacra, a missionary who was infected with Ebola in Liberia and was successfully treated at the Nebraska Medical Center. Credit Brendan Sullivan/Omaha World-Herald, via Associated Press

SCIENCE MAGAZINE                             Oct. 30, 2014

A study to assess the effectiveness of containment strategies, using a stochastic model of Ebola transmission between and within the general community, hospitals, and funerals, calibrated to incidence data from Liberia.

ABSTRACT

The ongoing Ebola outbreak poses an alarming risk to the countries of West Africa and beyond. To assess the effectiveness of containment strategies, we developed a stochastic model of Ebola transmission between and within the general community, hospitals, and funerals, calibrated to incidence data from Liberia. We find that a combined approach of case isolation, contact tracing with quarantine and sanitary funeral practices must be implemented with utmost urgency in order to reverse the growth of the outbreak. Under status quo intervention, our projections indicate that the Ebola outbreak will continue to spread, generating a predicted 224 (95% CI: 134 – 358) cases daily in Liberia alone by December, highlighting the need for swift application of multifaceted control interventions.

VOICE OF AMERICA                                                              Oct. 31, 2014

By Al Pessin

The international community must do more to fill "alarming gaps" in the fight against the Ebola epidemic, U.S. ambassador to the United Nations Samantha Power said to an audience in Brussels as she headed home from a visit to the three hardest-hit countries in West Africa.

U.S. Ambassador to the United Nations Samantha Power speaks during a lecture regarding the Ebola virus at the Residence Palace in Brussels, Oct. 30, 2014.

Power said the initial international response is making a difference, and has created what she called “the first tangible signs that the virus can and will be beaten.”

But, she said, many countries have not done enough, and urged them to not assume the job is done...

She called for more flexible planning, faster decision-making, and for support for the affected countries as they try to rebuild and expand their health care systems. Those systems were inadequate before the epidemic and have now been devastated by the deaths of hundreds of doctors and nurses.