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The Ebola Treatment You Haven't Heard Of

FORBES       by David Kroll                                                                                              Dec. 19, 2014

Pharmaceuticals and biotechnology-derived products have attracted the greatest public and professional interest in treating victims of Ebola virus disease. But a privately-held, small company with a treatment for shock and multi-organ failure may be the dark horse victor in the race to stop the West African outbreak. LB1148 from San Diego-based Leading BioSciences is starting Phase 2 clinical trials that build on 12 years of NIH-funded research to address an underappreciated, common denominator in shock and organ failure, including shock caused by Ebola infection.

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http://www.forbes.com/sites/davidkroll/2014/12/19/the-ebola-treatment-you-havent-heard-of/

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Screening Test Finds Drugs That Show Promise Against Ebola

U.S. NEWS AND WORLD REPORT HEALTH TODAY   by   Dennis Thompson                            Dec. 17, 2014

A screening test has identified more than 50 drugs that could be helpful in treating people with Ebola, researchers report.

"These drugs are all approved (by the FDA) so they could be deployed quickly if follow-up research proves that they are effective," said study author Adolfo Garcia-Sastre, director of the Global Health and Emerging Pathogens Institute with the Icahn School of Medicine at Mount Sinai in New York City.

The study was published online Dec. 17 in the journal Emerging Microbes and Infections.

The screening test involves a laboratory-engineered fake Ebola virus. The fake virus contains two proteins from the deadly pathogen, but does not include the infectious genetic material that makes Ebola so dangerous, Garcia-Sastre said.

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http://health.usnews.com/health-news/articles/2014/12/17/screening-test-finds-drugs-that-show-promise-against-ebola

Read Emerging Microbes and Infections paper.

http://www.nature.com/emi/journal/v3/n12/full/emi201488a.html

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Here’s How Much the Next Ebola Will Cost Us

Why saving the environment can help prevent it

TIME MAGAZINE     by Alexandra Sifferlin                                                                         Dec. 16, 2014

The global community cannot withstand another Ebola outbreak: The World Bank estimates the two-year financial burden price tag of the current epidemic at $32.6 billion. Unfortunately, the virus has revealed gaping holes in our preparedness for major infectious disease epidemics. Because of these, plus the urbanization of rural communities and globalization of travel and trade, more of these epidemics are expected.

In a new report from the EcoHealth Alliance published in the journal Proceedings of the National Academy of Sciences (PNAS), experts estimate that the world will see about five new emerging infectious diseases each year and that we need new prevention strategies to cut economic losses.

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Contest Seeks Novel Tools for the Fight Against Ebola

NEW YORK TIMES  by Donald G. McNeil, Jr.                                                                              Dec. 13, 2014

NEW YORK --The well-prepared Ebola fighter in West Africa may soon have some new options: protective gear that zips off like a wet suit, ice-cold underwear to make life inside the sweltering suits more bearable, or lotions that go on like bug spray and kill or repel the lethal virus.

A prototype for one of the protective suits in contention for the U.S.A.I.D. "Grand Challenges" award. Credit John Hopkins University/Jhpiego

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UNICEF Expanding Fight Against Ebola

VOICE OF AMERICA  Lisa Schlein                                                                                            Dec. 12, 2014

GENEVA—The U.N. Children’s Fund is appealing for an additional $300 million to expand its fight against Ebola in the three heavily affected West African countries over the next six months. UNICEF said gaining the confidence of community members, increasing their awareness and knowledge of modes of transmission and prevention are key to winning the battle against this deadly disease.

Women in the village of Boukoloma, in Guinea’s southeastern forest region, listen to messages about Ebola prevention. (Photo courtesy of Christophe Boulierac / UNICEF)

UNICEF officials said money from the appeal would be used to tackle two major drivers of Ebola transmission: lack of early isolation of patients and unsafe burials.  Both of these issues are wound up with traditional cultural practices, which often have stymied aid agencies’ efforts to prevent people from getting infected with the disease and spreading it to others. 

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The Path to Zero Ebola Cases

Op-ed

NEW YORK TIMES by Jim Yong Kim, President of the World Bank Group      Dec. 11, 2014                                              

MONROVIA, Liberia — In my career as a medical doctor and global health policy maker, I have been in the middle of monumental struggles, including fights to make treatment accessible in the developing world for those living with H.I.V./AIDS as well as multi-drug resistant tuberculosis. But the Ebola epidemic is the worst I’ve ever seen...

Members of District 13 ambulance service disinfect a room in a village north of Monrovia, Liberia. Credit Jerome Delay/Associated Press

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UN Says Several Months Needed to Control Ebola

ASSOCIATED PRESS by EDITH M. LEDERER                       Dec. 11, 2014

UNITED NATIONS-- The U.N. Ebola chief said Thursday it will take several more months before the outbreak in West Africa is under control, an assessment that makes clear the World Health Organization's goal of isolating 100 percent of Ebola cases by Jan. 1 won't be met.

Dr. David Nabarro said there has been "a massive shift" over the last four months in the way affected governments have taken the lead in responding to the epidemic, communities are taking action and the international community has pitched in.

But he said greater efforts are needed to combat Ebola in western Sierra Leone and northern Mali, to reduce the number of new cases in Liberia and to limit transmission to Mali.

WHO conceded that it didn't meet an interim Dec. 1 target of isolating 70 percent of Ebola patients and safely burying 70 percent of victims in hardest-hit Sierra Leone. But it hasn't made clear what that means for its Jan. 1 goal, which it set in September. It has acknowledged that its patchy data could compromise the goal, since the agency does not know how many Ebola patients there actually are and is unable to track all of their contacts.

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UN Says Several Months Needed to Control Ebola

ASSOCIATED PRESS by EDITH M. LEDERER                       Dec. 11, 2014

UNITED NATIONS-- The U.N. Ebola chief said Thursday it will take several more months before the outbreak in West Africa is under control, an assessment that makes clear the World Health Organization's goal of isolating 100 percent of Ebola cases by Jan. 1 won't be met.

Dr. David Nabarro said there has been "a massive shift" over the last four months in the way affected governments have taken the lead in responding to the epidemic, communities are taking action and the international community has pitched in.

But he said greater efforts are needed to combat Ebola in western Sierra Leone and northern Mali, to reduce the number of new cases in Liberia and to limit transmission to Mali.

WHO conceded that it didn't meet an interim Dec. 1 target of isolating 70 percent of Ebola patients and safely burying 70 percent of victims in hardest-hit Sierra Leone. But it hasn't made clear what that means for its Jan. 1 goal, which it set in September. It has acknowledged that its patchy data could compromise the goal, since the agency does not know how many Ebola patients there actually are and is unable to track all of their contacts.

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Ebola response roadmap - Situation report

WHO                                                                                                                       Dec. 10, 2014

A total of 17 942 confirmed, probable, and suspected cases of Ebola virus disease (EVD) have been reported in five affected countries (Guinea, Liberia, Mali, Sierra Leone, and the United States of America) and three previously affected countries (Nigeria, Senegal and Spain) up to the end of 7 December. There have been 6388 reported deaths.

Reported case incidence is slightly increasing in Guinea (103 confirmed and probable cases reported in the week to 7 December), declining in Liberia (29 new confirmed cases in the 3 days to 3 December), and may still be increasing in Sierra Leone (397 new confirmed cases in the week to 7 December). The case fatality rate across the three most-affected countries in all reported cases with a recorded definitive outcome is 76%; in hospitalized patients the case fatality rate is 61%.

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http://www.who.int/csr/disease/ebola/situation-reports/en/

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Ebola outbreak: Virus still 'running ahead of us', says WHO

BBC    by Tulip Mazumdar                                                                                                    Dec. 10, 2014

The Ebola virus that has killed thousands in West Africa is still "running ahead" of efforts to contain it, the head of the World Health Organization has said.
Director general Margaret Chan said the situation had improved in some parts of the worst-affected countries, but she warned against complacency.

The risk to the world "is always there" while the outbreak continues, she said.

She said the WHO and the international community failed to act quickly enough....

"It is fair to say the whole world, including WHO, failed to see what was unfolding, what was going to happen in front of our eyes," said Dr Chan.

"Of course, with the benefit of hindsight, if you ask me now... we could have mounted a much more robust response."

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http://www.bbc.com/news/health-30400304

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