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Ebola rapid diagnostic kit developed by UK scientists in Sierra Leone

Doctors says the kit, if approved by health authorities, could transform the admissions process with its capacity to deliver results within 20 minutes

THE GUARDIAN    by Lisa O'Carroll                              March 29, 2015

A rapid Ebola diagnostic kit similar to a pregnancy kit has been developed by British military scientists and NHS medics in Sierra Leone.

Health care workers prepare to entering a high risk zone at an Ebola virus clinic in Sierra Leone, where the diagnostic kit has been undergoing tests. Photograph: Michael Duff/AP

It can be administered at the bedside and return its first results within 20 minutes, slashing dramatically the normal 24-hour turnaround for lab results.

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Ebola pioneer, stem cell researcher honoured with Canada Gairdner Awards

CANADIAN PRESS                                                                                March 25, 2015
One of the co-discoverers of the Ebola virus and a leading Canadian stem cell researcher are among this year's winners of the prestigious Canada Gairdner Awards.

Dr. Peter Piot is the recipient of the Canada Gairdner Global Health Award, recognizing his work on the discovery of the Ebola virus in 1976 and his leadership in the global response to the HIV-AIDS epidemic.

Dr. Janet Rossant, chief of research at Toronto's Hospital for Sick Children, is the recipient of the 2015 Canada Gairdner Wightman Award, which honours a Canadian who has demonstrated outstanding leadership in medicine and medical science.

Five international scientists are also being honoured with Canada Gairdner Awards, two each from the United States and Japan and one from Switzerland....

Dr. Peter Piot won the 2015 Canada Gairdner Global Health Award in recognition of his work on the discovery of the Ebola virus in 1976 and his leadership in the global response to the HIV-AIDS epidemic. (David Azia/Associated Press)

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How to stop the next epidemic

THE ECONOMIST                                                                                    May 19, 2015

..when the next epidemic breaks out, how do we prevent it from spreading around the world? It is easier said than done.
 
First: Early detection is critical, and it relies on good surveillance. But only 64 of the 194 member states of the World Health Organisation (WHO) have the surveillance procedures, laboratories and data-management capabilities required by the International Health Regulations. Improvements in things like basic public health infrastructure are needed...

Second: A swift response to an outbreak – which might involve getting skilled people, equipment and money to the right places – can potentially save more lives than drugs and vaccines. ... The World Health Organisation and the global community were slow to recognise that there was an international public health emergency.

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Ebola-proof tablet designed by Google rolled out in Sierra Leone disease centre

THE TELEGRAPH by Aislinn Laing                                                                         March 20, 2015

An Ebola-proof tablet that can survive being doused in chlorine and can be used while wearing gloves has been developed by Google and technology volunteers for use by health workers in Sierra Leone.

 

MSFStaff testing one of the Clinical Management Tablets at the Magburaka treatment centre in Sierra Leone Photo: MSF

The Android device, based in a waterproof Sony Xperia with an extra protective casing, allows medics to safely record and share patient temperatures and symptoms over days and weeks....

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FDA panel to discuss Ebola vaccine development in May

REUTERS                                                    March 18, 2015

WASHINGTON ==The U.S. Food and Drug Administration said an advisory panel will discuss the development of Ebola vaccines, days after an American health worker was flown back after being tested positive for Ebola in Sierra Leone.

The federal health regulator would discuss the development of vaccines on May 12, it announced on its website on Wednesday.

The resurgence of the virus last year prompted drugmakers from across the world to develop new treatments that are in different stages of studies....

The World Health Organization said it will decide on mass vaccination against the virus in August.

See full story.

http://www.reuters.com/article/2015/03/18/us-health-ebola-fda-idUSKBN0ME1D520150318
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See Federal Register notice of meeting.

https://www.federalregister.gov/articles/2015/03/17/2015-06116/vaccines-and-related-biological-products-advisory-committee-notice-of-meeting

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Ebola vaccine trial to combine GSK, Emergent Bio shots

REUTERS                                                                                                          March 16, 2015

LONDON  - Scientists are to test a new two-shot Ebola vaccine using an experimental shot from Britain's GlaxoSmithKline, which is already in clinical trials in Africa, and a new kind of booster from Emergent BioSolutions.

A health worker, left, injects a man in his arm with an Ebola vaccine in Conakry, Guinea, March 7, 2015. The World Health Organization is starting large-scale testing of an experimental Ebola vaccine in Guinea  to see how effective it might be in preventing future outbreaks of the deadly virus.  (AP Photo/ Youssouf Bah)

The Maryland-based biotech company said on Monday its modified vaccinia Ankara (MVA) Ebola Zaire vaccine would be used in an initial Phase I clinical study to be conducted by researchers at the University of Oxford.

Although Ebola case numbers have fallen to a low level, drug companies are still pushing ahead with efforts to develop an effective vaccine, which may help fight the next outbreak, even if it does not come in time for the current epidemic.

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WHO May Lose Credibility After Ebola

Agency seeks a new model after flaws revealed by Ebola crisis.

COMMENTARY MEDPAGE TODAY by Michael Smith            Feb. 15, 2015 

As the Ebola epidemic drags on, the World Health Organization is in danger of losing its credibility as a bulwark against infectious disease.

The West African epidemic is a "mega-crisis (that) overwhelmed the capacity of WHO," according to Director-General Margaret Chan, MD, speaking to reporters in late January.

To prevent a similar crisis in the future, Chan has proposed a package of reforms, including a large contingency fund for emergencies, an increase in the number of trained people able to deploy quickly to a crisis site, and structural changes to streamline the famously unwieldy organization.

Whether those get anywhere is the vital question, according to Lawrence Gostin, JD, of the O'Neill Institute for National and Global Health Law at Washington's Georgetown University.

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UK should resume flights to Ebola-hit nations: parliamentary watchdog

REUTERS   by  Katie Nguyen                                                                                       Feb. 11, 2015

LONDON - Britain's decision to stop direct flights to Ebola-hit countries had "no scientific justification", probably increased the cost of dealing with the outbreak and should be reversed, a parliamentary watchdog said on Wednesday.

Several airlines including British Airways and Emirates stopped flights last year to countries in West Africa affected by the worst outbreak of Ebola since the deadly virus was identified in 1976.

In September, independent health advisers to the World Health Organization (WHO) concluded that there should be no general ban on travel or trade with Ebola-affected areas....

The committee also criticized the Department for International Development (DFID) for failing to respond to the crisis with enough urgency. It said DFID should focus on strengthening healthcare systems in the region so they could cope better with future public health emergencies.
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http://news.yahoo.com/uk-resume-flights-ebola-hit-nations-parliamentary-watchdog-132034795--finance.html;_ylt=AwrBEiHpi9tUnhAA7srQtDMD

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Ebola infection 'linked to visor'

THE PRESS ASSOCIATION                               Feb. 4, 2015
LONDON --A British nurse who contracted Ebola while working in Sierra Leone possibly caught the virus by wearing a visor and not goggles, an investigation has suggested.
Press Association - Save the Children said Pauline Cafferkey, pictured on her return to health, may have contracted Ebola by wearing a visor rather than goggles when treating patients in Sierra Leone

The report by Save the Children said it cannot be completely certain how Pauline Cafferkey contracted Ebola but said both pieces of equipment are "equally safe".

The nurse, from Cambuslang in South Lanarkshire, had volunteered with the charity at the Ebola Treatment Centre (ETC) in Kerry Town before returning to the UK in December....

Save the Children published the findings of an independent review into the possible causes of how the 39-year-old caught the virus. The report said both visors and goggles are safe but there are slight differences in the type of clothing worn with each and in the protocols for putting them on and removing them....

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In pursuit of next-generation Ebola stockpile vaccines

REUTERS   by Kate Kell and Ben Herschler                                                                        Feb. 1. 2015
LONDON --As West Africa's devastating Ebola outbreak begins to dwindle, scientists are looking beyond the endgame at the kind of next-generation vaccines needed for a vital stockpile to hit another epidemic hard and fast.

 

Research assistant Georgina Bowyer works on a vaccine for Ebola at The Jenner Institute in Oxford, southern England January 16, 2015. Credit: Reuters/Eddie Keogh

Determined not to lose scientific momentum that could make the world's first effective Ebola interventions a reality, researchers say the shots, as well as being proven to work, must be cheap, easy to handle in Africa and able to hit multiple virus strains.

That may mean shifting focus from the stripped-down, fast-tracked vaccine development ideas that have dominated the past six months, but it mustn't mean the field gets bogged down in complexities.

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